The DIANT® LARU – Benchtop LNP Processing

About the DIANT LARU (With NanoFlowSizer™)

DIANT®’s benchtop LARU (lab and research unit) is a laboratory nanoparticle synthesis system suitable for R&D, academic work, and training operations. Its processes are scalable up to the larger DIANT® LiFT system.

The LARU’s continuous nanoparticle processing offers inline dilution, drug loading, and nanoparticle modification, leading to higher efficacy and encapsulation than batch processing.

Nanoparticle Manufacturing with the LARU

The LARU is a pilot-scale system that can continuously produce lipid nanoparticles (LNPs), liposomes, nucleic acid/lipid complexes, polymeric micelles, suspensions, and emulsions.


  • Scales up from R&D to commercial cGMP manufacturing
  • Performs continuous or batch operations
  • Produces nanoparticles of various sizes: ~25 d.nm to >500 d.nm
  • Collects volumes as low as 20 mL (short runs)
  • Has standard connections for bottles, tubes, or 2D bags for ease of use

Solvent Injection

The LARU features DIANT® Jet technology, a patented single-jet, low flow rate, low dead volume (LDV) solvent injection system for high throughput.

Process Analytical Technology (PAT) via NanoFlowSizer™

As the exclusive distributor of the NanoFlowSizer™ in the United States, DIANT’s systems work with InProcess-LSP’s unique particle size analyzer technology in order to non-invasively characterize nanoparticles inline:

  • Integrated, inline particle size control and monitoring with InProcess-LSP’s NanoFlowSizer™, SR-DLS
  • Automatic particle size control can enable rapid runs of 20 seconds for determining optimal particle size for your experiments
  • Real-time particle monitoring, such as inline lipid analysis

Multiple Program Options

Store and create runtime recipes for producing particles under different flow conditions and set durations.

DIANT® LARU Specifications

Details about the DIANT® LARU, our scalable benchtop nanoparticle synthesis system:

  • Dimensions: 30 x 30 x 12 in. (76 x 76 x 30 cm)
  • Maximum output flow rate: 400 mL/min
  • Solvent flow rate: 20 mL/min
  • Flow rate ratio: 2-8
  • Dilution port
  • Touch-screen HMI
  • Data logging
  • Voltage & frequency: 100-240 V & 50/60 Hz

DIANT® LARU Add-Ons and Continuous Processing Systems

Optional add-ons that are available for the DIANT® LARU include:

  • Customized PAT integration
  • Particle size analyzer
  • pH monitor/probes
  • Conductivity
  • Temperature control – Control the temperature of your sample at each stage with the water circulator, sold separately

Continuous Processing from LARU to 2TFF and IEM

Single-Pass, Closed Process


The 2TFF uses a proprietary multi-stage tangential flow filtration system to reduce biofouling and allow for long duration runs. Concentrates particles using a closed system, operating in single-pass mode.


The DIANT® IEM is a continuous processing system for the
controlled modification of pre-formed vesicular nanoparticles:

  • Intravesicular aqueous modifications – small molecules like liposomes can be actively loaded to promote drug encapsulation
  • Extravesicular surface modifications – capabilities include adding polymeric coating and active drug moieties


The IEM system can:

  • Perform one or several simultaneous nanoparticle modifications as a continuous process
  • PEGylate particles, including LNPs, polymeric micelles, and others
  • Decorate particles
  • Manage growth kinetics
    • Salt loading for liposomes
    • Surface deposition for LNPs
  • Perform PAT – inline UV-Vis with model prediction (optional & customizable)
  • Sense pressure, conductivity, and temperature
  • Perform inline heat exchange and mixing
  • Perform inline bioburden reduction filtration at collection
  • Perform inline single-pass concentration

Want to learn more about the DIANT® LARU?

Get in touch with a DIANT sales representative today to learn more about our systems and services and discuss how the LARU can help increase speed to market for your nanoparticle project. Leasing options are now available.