Systems
The DIANT® LARU
About the DIANT LARU (With NanoFlowSizer™)
The LARU’s continuous nanoparticle processing offers inline dilution, drug loading, and nanoparticle modification, leading to higher efficacy and encapsulation than batch processing.
Nanoparticle Manufacturing with the LARU
The LARU is a pilot-scale system that can continuously produce lipid nanoparticles (LNPs), liposomes, nucleic acid/lipid complexes, polymeric micelles, suspensions, and emulsions.
The LARU:
- Scales up from R&D to commercial cGMP manufacturing
- Performs continuous or batch operations
- Produces nanoparticles of various sizes: ~25 d.nm to >500 d.nm
- Collects volumes as low as 20 mL (short runs)
- Has standard connections for bottles, tubes, or 2D bags for ease of use
Solvent Injection
The LARU features DIANT® Jet technology, a patented single-jet, low flow rate, low dead volume (LDV) solvent injection system for high throughput.
Process Analytical Technology (PAT) via NanoFlowSizer™
As the exclusive distributor of the NanoFlowSizer™ in the United States, DIANT’s systems work with InProcess-LSP’s unique particle size analyzer technology in order to non-invasively characterize nanoparticles inline:
- Integrated, inline particle size control and monitoring with InProcess-LSP’s NanoFlowSizer™, SR-DLS
- Automatic particle size control can enable rapid runs of 20 seconds for determining optimal particle size for your experiments
- Real-time particle monitoring, such as inline lipid analysis
Multiple Program Options
Store and create runtime recipes for producing particles under different flow conditions and set durations.
DIANT® LARU Specifications
Details about the DIANT® LARU, our scalable benchtop nanoparticle synthesis system:
- Dimensions: 30 x 30 x 12 in. (76 x 76 x 30 cm)
- Maximum output flow rate: 400 mL/min
- Solvent flow rate: 20 mL/min
- Flow rate ratio: 2-8
- Dilution port
- Touch-screen HMI
- Data logging
- Voltage & frequency: 100-240 V & 50/60 Hz
DIANT® LARU Add-Ons and Continuous Processing Systems
Optional add-ons that are available for the DIANT® LARU include:
- Customized PAT integration
- Particle size analyzer
- pH monitor/probes
- Conductivity
- Temperature control – Control the temperature of your sample at each stage with the water circulator, sold separately
Continuous Processing from LARU to 2TFF and IEM
Single-Pass, Closed Process
DIANT® LARU + 2TFF
The 2TFF uses a proprietary multi-stage tangential flow filtration system to reduce biofouling and allow for long duration runs. Concentrates particles using a closed system, operating in single-pass mode.
DIANT® LARU + IEM
The DIANT® IEM is a continuous processing system for the
controlled modification of pre-formed vesicular nanoparticles:
- Intravesicular aqueous modifications – small molecules like liposomes can be actively loaded to promote drug encapsulation
- Extravesicular surface modifications – capabilities include adding polymeric coating and active drug moieties
The IEM system can:
- Perform one or several simultaneous nanoparticle modifications as a continuous process
- PEGylate particles, including LNPs, polymeric micelles, and others
- Decorate particles
- Manage growth kinetics
- Salt loading for liposomes
- Surface deposition for LNPs
- Perform PAT – inline UV-Vis with model prediction (optional & customizable)
- Sense pressure, conductivity, and temperature
- Perform inline heat exchange and mixing
- Perform inline bioburden reduction filtration at collection
- Perform inline single-pass concentration